The exit of lymphocytes from the vasculature is essential for the control of the inflammatory response. Cell migration involves cytoskeletal dynamics controlled by Rac GTPases but the full molecular ...

In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system ...

The current understanding of lymphocyte migration across the endothelium includes four steps: attachment, rolling, arrest and diapedesis. In June Nature Immunology new evidence from researchers at The ...

In the 1950s, T cells were yet to be described and the functions of lymphocytes were unknown. But animal experiments had shown that each day, enough lymphocytes enter the blood from the main ...